2-(3',4'-Diamino-biphenyl-2-sulfonyl)-ethanol → HCID 178504704、化合物
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([S:15]([CH2:18]CO)(=[O:17])=[O:16])=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[NH2:8].Cl.C(O[C:25](=N)[CH2:26][Br:27])C>C(O)C>[Br:27][CH2:26][C:25]1[NH:8][C:7]2[CH:6]=[CH:5][C:4]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[S:15]([CH3:18])(=[O:16])=[O:17])=[CH:3][C:2]=2[N:1]=1参加物
4
実験手順
A mixture of 2-(3′,4′-diamino-biphenyl-2-sulfonyl)-ethanol (0.140 g, 0.479 mmol) and 2-bromoacetimidic acid ethyl ester hydrochloride salt (0.116 g, 0.575 mmol) in anhydrous ethanol (100%, 6 mL) was stirred at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate and brine. The organic layer was dried over Na2SO4, filtered, and the filtrate was concentrated in vacuo to provide 2-bromomethyl-5-(2-methanesulfonyl-phenyl)-1H-benzoimidazole as yellow oil (0.178 g, 94%).