Hydrochloric Acid → 4-{5-[4-(2-aminoethyl)phenoxy]pentyl}-2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenol bis hydrochloride salt

HRID 1433290ノート

反応式

HRID 1433290 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([C@@H:29]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH2:30][CH2:31][N:32]([CH:36]([CH3:38])[CH3:37])[CH:33]([CH3:35])[CH3:34])[CH:23]=2)=[CH:12][CH:11]=1)(C)(C)C.C(O)C.[ClH:49]>ClCCl.C(OCC)C>[ClH:49].[ClH:49].[NH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([C@@H:29]([C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[CH2:30][CH2:31][N:32]([CH:36]([CH3:37])[CH3:38])[CH:33]([CH3:34])[CH3:35])[CH:23]=2)=[CH:14][CH:15]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 57933162tert-butyl(2-{4-[(5-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}pentyl)oxy]phenyl}ethyl)carbamate

生成物 1

HCID 866164904-{5-[4-(2-aminoethyl)phenoxy]pentyl}-2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenol bis hydrochloride salt

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl(2-{4-[(5-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}pentyl)oxy]phenyl}ethyl)carbamate (Preparation 58, 1.66 g, 2.69 mmol) was dissolved in dichloromethane (20 ml) and ethanol (3 ml) and hydrochloric acid (12 ml of a 2M solution in diethyl ether) was added, and the mixture stirred overnight at room temperature. Solvent was removed in vacuo and the residue dissolved in dichloromethane and solvent removed in vacuo again to furnish the title compound as a yellow foam, 1.6 g

後処理

  1. customSolvent was removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. customsolvent removed in vacuo again

出典と根拠

ORDレコード
ord-cb7752e42b57417caba59a5f1dd757f0
出典データセット
uspto-grants-2009_11
特許番号
US07612084B2

反応ノート

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