(Iodomethyl)cyclopentane → (3S,5S)-3-(Cyclopentylmethyl)-3-methyl-5-phenylmorpholin-2-one

HRID 1433318ノート

反応式

HRID 1433318 の反応式
[CH3:1][C:2]1[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.I[CH2:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH2:16][C@@:2]2([CH3:1])[C:3](=[O:14])[O:4][CH2:5][C@H:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[NH:7]2)[CH2:21][CH2:20][CH2:19][CH2:18]1

参加物

3

反応物 2

HCID 2762531(Iodomethyl)cyclopentaneHCID 57467834(5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

生成物 1

HCID 57935240(3S,5S)-3-(Cyclopentylmethyl)-3-methyl-5-phenylmorpholin-2-one

実験手順

The compound was prepared according to the procedure outlined in Preparation 1 using (5S)-3-methyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one (1 g, 5.28 mmol, see WO-A-02/051983) and (iodomethyl)cyclopentane. The total amount of compound synthesised was 0.426 g.

後処理

  1. customThe compound was prepared
  2. customThe total amount of compound synthesised

出典と根拠

ORDレコード
ord-558f2c2f0f98440c8da23e4e2696968f
出典データセット
uspto-grants-2009_11
特許番号
US07612226B2

反応ノート

読み込み中…