1H-Benzotriazole-1-methanol → N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline

HRID 1433679

反応式

HRID 1433679 の反応式
[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([F:16])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:17]1([CH2:26]O)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1>CO>[N:17]1([CH2:26][NH:13][C:12]2[CH:14]=[CH:15][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]=2[F:16])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

参加物

4

反応物 2

HCID 2241691H-Benzotriazole-1-methanolHCID 114998094-(Benzyloxy)-2-fluoroaniline

生成物 1

HCID 22936313N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline収率 66.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After dissolving 4-benzyloxy-2-fluoroaniline (11.25 g, 51.78 mmol) in methanol (300 ml), 1H-benzotriazole-1-methanol (8.11 g, 54.37 mmol) was added and the mixture was stirred for 10 hours at room temperature. The precipitated crystals were filtered out, washed with ethanol and dried by aspiration to obtain the title compound (12.01 g, 34.47 mmol, 66.57%) as colorless crystals.

後処理

  1. additionwas added
  2. filtrationThe precipitated crystals were filtered out
  3. washwashed with ethanol
  4. customdried by aspiration

出典と根拠

ORDレコード
ord-9e59ddef9c64489fac122ed230b84c43
出典データセット
uspto-grants-2009_11
特許番号
US07612092B2

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