3-Bromoanisole → (2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone

反応式

[Br:1][C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.Cl.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=1[O:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)[C:15](O)=[O:16]>>[Br:1][C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][C:7]=1[C:15]([C:14]1[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[C:12]([F:11])[CH:13]=1)=[O:16]

参加物

反応物 2

HCID 169713-Bromoanisole

HCID 666268273-Fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride

生成物 1

HCID 57934302(2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone

実験手順

Synthesized from 3-bromoanisole (1.1 ml) and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride (3.3 g) according to an analogous synthetic method to Preparation Example 66, the title compound (1.6 g) was obtained.

後処理

customaccording to an analogous synthetic method to Preparation Example 66

出典と根拠

ORDレコード: ord-ab67ae36e4104acc95554d6316b589b9
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07612114B2

反応ノート

読み込み中…