1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine → 3-[3-Fluoro-4-(2-piperidin-1-ylethoxy)phenylamino]-4-naphthalen-2-ylphenol
反応式
BrC1C=CC(OCCN2CCCCC2)=C(F)C=1.[F:18][C:19]1[CH:20]=[C:21]([NH:34][C:35]2[CH:40]=[C:39]([O:41]C)[CH:38]=[CH:37][C:36]=2[C:43]2[CH:52]=[CH:51][C:50]3[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH:44]=2)[CH:22]=[CH:23][C:24]=1[O:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[F:18][C:19]1[CH:20]=[C:21]([NH:34][C:35]2[CH:40]=[C:39]([OH:41])[CH:38]=[CH:37][C:36]=2[C:43]2[CH:52]=[CH:51][C:50]3[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH:44]=2)[CH:22]=[CH:23][C:24]=1[O:25][CH2:26][CH2:27][N:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1参加物
3
実験手順
Synthesized from 5-methoxy-2-naphthalen-2-ylamine and 1-[2-(4-bromo-2-fluorophenoxy)ethyl]piperidine according to an analogous synthetic method to Example 116, [3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl](5-methoxy-2-naphthalen-2-ylphenyl)amine (350 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (293 mg).