3-Fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride → 4-{2-{2-[3-Fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]phenyl}vinyl}phenol
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16]C(=O)C)=[CH:12][CH:11]=1.Cl.[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[O:31][CH2:32][CH2:33][N:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1)[C:25](Cl)=O>>[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[O:31][CH2:32][CH2:33][N:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1)[CH2:25][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]=[CH:9][C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=1参加物
3
実験手順
Synthesized from acetic acid 4-[2-(2-aminophenyl)vinyl]phenyl ester (328 mg) and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride (500 mg) according to an analogous synthetic method to Example 152, the title compound (365 mg) was obtained.
出典と根拠
- ORDレコード
- ord-e8f71dee20f34c499780f843335587cb
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612114B2
反応ノート
読み込み中…