4-Benzyloxybenzylamine → (4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

HRID 1434438

反応式

HRID 1434438 の反応式
FC(F)(F)S(O[C:7]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[CH2:11]2)(=O)=O.C(OC1C=CC(CN)=CC=1)C1C=CC=CC=1.[CH2:44]([O:51][C:52]1[CH:78]=[CH:77][C:55]([CH2:56][NH:57][C:58]2C=C(OC)C=C3C=2CC(C2C=CC(OC)=CC=2)C3)=[CH:54][CH:53]=1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[CH2:44]([O:51][C:52]1[CH:53]=[CH:54][C:55]([CH2:56][NH:57][CH2:58][C:7]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]3[C:8]=2[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH2:11]3)=[CH:77][CH:78]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

参加物

4

反応物 3

HCID 42928454-BenzyloxybenzylamineHCID 230872886-Methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonateHCID 66627646HCID 66627646、化合物

生成物 1

HCID 66626750(4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

実験手順

Synthesized from 6-methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonate and 4-benzyloxybenzylamine according to an analogous synthetic method to Example 116, (4-benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]amine (1.2 g) was used according to an analogous synthetic method to Preparation Example 18 to provide the title compound (1.0 g).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 18

出典と根拠

ORDレコード
ord-bdaefb2622ee477a80319fb0de2a010f
出典データセット
uspto-grants-2009_11
特許番号
US07612114B2

関連ノート

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