Morpholine → HCID 57935884、化合物

HRID 1434511ノート

反応式

HRID 1434511 の反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Br:13])[CH:8]=2)[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>ClCCl>[Cl:1][C:2]1[N:11]=[C:10]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Br:13])[CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 101075686-Bromo-2,4-dichloroquinazoline

生成物 1

HCID 57935884HCID 57935884、化合物収率 67.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Crude 2,4-Dichloro-6-bromoquinazoline (18.8 g.) was dissolved in dichloromethane (500 mL) and chilled in a dry ice bath. To the solution was added morpholine (11.6 g.) and it was stirred for two hours. The organic layer was washed with saturated ammonium chloride solution (2×200 mL), dried with sodium sulfate, and evaporated. The resulting solid was washed with ether, and dried to give 2-chloro-4-morpholino-6-bromoquinazoline (15.0 g.).

後処理

  1. temperaturechilled in a dry ice bath
  2. washThe organic layer was washed with saturated ammonium chloride solution (2×200 mL)
  3. dry with materialdried with sodium sulfate
  4. customevaporated
  5. washThe resulting solid was washed with ether
  6. customdried

出典と根拠

ORDレコード
ord-88bdca82b663491a86a8d362b55f58e9
出典データセット
uspto-grants-2009_11
特許番号
US07615552B2

反応ノート

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