Triethylamine → 1-[1-(3-chloro-3-phenylpropyl)piperidin-4-yl]-5-(methylsulfonyl)-1H-benzimidazole

HRID 1434592ノート

反応式

HRID 1434592 の反応式
CS([Cl:5])(=O)=O.[CH3:6][S:7]([C:10]1[CH:34]=[CH:33][C:13]2[N:14]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)O)[CH2:19][CH2:18]3)[CH:15]=[N:16][C:12]=2[CH:11]=1)(=[O:9])=[O:8].C(N(CC)CC)C>ClCCl>[Cl:5][CH:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:24][CH2:23][N:20]1[CH2:21][CH2:22][CH:17]([N:14]2[C:13]3[CH:33]=[CH:34][C:10]([S:7]([CH3:6])(=[O:9])=[O:8])=[CH:11][C:12]=3[N:16]=[CH:15]2)[CH2:18][CH2:19]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68704632HCID 68704632、化合物

生成物 1

HCID 579360111-[1-(3-chloro-3-phenylpropyl)piperidin-4-yl]-5-(methylsulfonyl)-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methanesulphonyl chloride (0.46 ml) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol (2.1 g) and triethylamine (0.9 ml) in dichloromethane (30 ml) at 0° C. The mixture was allowed to warm to room temperature and stirring was continued for 16 hours. The reaction mixture was washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave the title compound as an orange foam, yield 1.85 g, M+H 432.

後処理

  1. washThe reaction mixture was washed with water (15 ml) and brine (15 ml)
  2. customdried
  3. customRemoval of the solvent

出典と根拠

ORDレコード
ord-bcbab8cc4ebf4c97bbb1eab318b4c20c
出典データセット
uspto-grants-2009_11
特許番号
US07615555B2

反応ノート

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