Potassium Carbonate → HCID 57935976、化合物

HRID 1434593ノート

反応式

HRID 1434593 の反応式
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH3:12][S:13]([C:16]1[CH:30]=[CH:29][C:19]2[N:20]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[CH:21]=[N:22][C:18]=2[CH:17]=1)(=[O:15])=[O:14].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:12][S:13]([C:16]1[CH:30]=[CH:29][C:19]2[N:20]([CH:23]3[CH2:24][CH2:25][N:26]([CH2:2][CH2:3][C:4]([C:6]4[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=4)=[O:5])[CH2:27][CH2:28]3)[CH:21]=[N:22][C:18]=2[CH:17]=1)(=[O:15])=[O:14]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 702953-ChloropropiophenoneHCID 58998518HCID 58998518、化合物

生成物 1

HCID 57935976HCID 57935976、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3-Chloropropiophenone (860 mg) was added to a mixture of 5-(methylsulfonyl)-1-piperidin-4-yl-1H-benzimidazole (1.395 g) and potassium carbonate (1.38 g) in DMF (30 ml) and stirred for 2 days. The reaction mixture was evaporated to dryness and the residue was dissolved in dichloromethane (20 ml), washed with water (15 ml) and brine (15 ml), dried and evaporated to dryness to give the title compound, yield 2.07 g, M+H 412, NMR (CDCl3) 2.2 (m, 4H) 2.3-2.4 (m, 2H) 2.9 (m, 2H) 3.1 (s, 3H) 3.2-3.3 (m, 4H) 4.3 (m, 1H) 7.5 (m, 2H) 7.6 (m, 2H) 7.9 (m, 2H) 8.0 (m, 1H) 8.2 (s, 1H) 8.4 (s, 1H).

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was dissolved in dichloromethane (20 ml)
  3. washwashed with water (15 ml) and brine (15 ml)
  4. customdried
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-7fb6528ba5244589b175c6f75cd62349
出典データセット
uspto-grants-2009_11
特許番号
US07615555B2

反応ノート

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