Acetic Anhydride → HCID 57935989、化合物

反応式

[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[N:17][N:16]=[CH:15]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:15]=[N:16][N:17]=[C:18]2[C:19](=[O:21])[CH3:20])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 21098257HCID 21098257、化合物

生成物 1

HCID 57935989HCID 57935989、化合物

実験手順

A solution of 1-benzyl-4-(4H-1,2,4-triazol-4-yl)piperidine (200 mg) in acetic anhydride (20 ml) was refluxed for 18 hours. The reaction mixture was concentrated under reduced pressure to a thick oil. Flash chromatography eluting with dischloromethane then 5% methanol in dichloromethane gave 1-[4-(1-benzylpiperidin-4-yl)-4H-1,2,4-triazol-3-yl]ethanone as a colourless oil (60 mg).

後処理

concentrationThe reaction mixture was concentrated under reduced pressure to a thick oil
washFlash chromatography eluting with dischloromethane

出典と根拠

ORDレコード: ord-dfcd9b83444f423b8a0a1e4b997feb9c
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07615555B2

反応ノート

読み込み中…

参加物