Ammonia → 3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17]C(=O)C(F)(F)F)=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])=[N:6][CH:7]=1.N>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To N-(5-chloropyridin-2-yl)-3-(trifluoroacetyl)amino-pyridine-2-carboxamide (1 g, 2.9 mmol) was added 5 mL of 2 M NH3 in MeOH. The reaction vessel was capped and heated to 50° C. for 12 h. The reaction mixture was cooled to 0° C. for 30 min and filtered to provide N-(5-chloropyridin-2-yl)-3-aminopyridine-2-carboxamide (0.72 g, 100%).
後処理
- customThe reaction vessel was capped
- temperatureThe reaction mixture was cooled to 0° C. for 30 min
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-71e8b26fada04d0f84a87b86a2d465d7
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07615568B2
反応ノート
読み込み中…