2-(Methylthio)-4-(tributylstannyl)pyrimidine → (E)-3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:12])/[CH:4]=[CH:5]/[C:6]1[S:7][C:8](Br)=[CH:9][CH:10]=1.[CH3:13][S:14][C:15]1[N:20]=[C:19]([Sn](CCCC)(CCCC)CCCC)[CH:18]=[CH:17][N:16]=1>>[CH3:1][O:2][C:3](=[O:12])/[CH:4]=[CH:5]/[C:6]1[S:7][C:8]([C:17]2[CH:18]=[CH:19][N:20]=[C:15]([S:14][CH3:13])[N:16]=2)=[CH:9][CH:10]=1参加物
3
実験手順
(E)-3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl ester was prepared analogous to Step A of Method D, using (E)-3-(5-bromo-thiophen-2-yl)-acrylic acid methyl ester and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine. Yield: 45%.
出典と根拠
- ORDレコード
- ord-086545ff375a4d74988dc106629f886e
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07615562B2
反応ノート
読み込み中…