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1-Benzothiophene-3-sulfonyl chloride → [4-Amino-2-[1-(benzo[b]thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzothiophene-3-sulfonyl chloride | HCID 2776340 | — |
| 反応物 | [4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone | HCID 9997668 | — |
| 生成物 | [4-Amino-2-[1-(benzo[b]thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone | HCID 21070416 | — |
反応手順
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and benzo[b]thiophene-3-sulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C25H25FN5O4S2 [(M+H)+] 542.1327, observed 542.1331.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07615634B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-eb96601d6ccd4dc2a7f617c743ccb42d |
| 出典メモ | uspto-grants-2009_11 |