[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 58777627、化合物

反応式

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:9])=[CH:6][N:5]=[C:4](S(CC)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:27][S:28]([N:31]1[CH2:36][CH2:35][CH:34]([NH2:37])[CH2:33][CH2:32]1)(=[O:30])=[O:29]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:9])=[CH:6][N:5]=[C:4]([NH:37][CH:34]2[CH2:35][CH2:36][N:31]([S:28]([CH3:27])(=[O:30])=[O:29])[CH2:32][CH2:33]2)[N:3]=1

参加物

反応物 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate

HCID 21070599HCID 21070599、化合物

生成物 1

HCID 58777627HCID 58777627、化合物

実験手順

The compound was prepared from (4-amino-2-ethylsulfinyl-pyrimidin-5-yl)-(3-methyl-thiophen-2-yl)-methanone (Example 197) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C16H22N5O3S2 [(M+H)+] 396.1159, observed 396.1162.

出典と根拠

ORDレコード: ord-a607799be23f46d78dc777bdeefd6555
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07615634B2

反応ノート

読み込み中…

参加物