化工社化工社 化学情報印刷レポート · 研究参考用
4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Thiazoleacetic acid, 2-amino-, ethyl ester | HCID 104454 | — |
| 反応物 | 4-(Trifluoromethyl)benzenesulfonyl chloride | HCID 2777399 | — |
| 生成物 | Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate | HCID 2814007 | — |
反応手順
The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-trifluoromethylbenzenesulfonyl chloride according to METHOD A, giving 0.14 g (33%) of an off-white solid after recrystallization from acetone/ether/petroleum ether: mp 174° C.; MS (Ionspray, [M+H]+) m/z 395; Anal. Calcd (found) for C14H13F3N2O4S2: C, 42.6 (42.4)%, H, 3.3 (2.8)%, N, 7.1 (6.8)%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618961B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-f7fa9f1e3ccc4fcfacbb9d2fa9059ea9 |
| 出典メモ | uspto-grants-2009_11 |