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4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl {2-[({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Thiazoleacetic acid, 2-amino-, ethyl ester | HCID 104454 | — |
| 反応物 | 5-[1-Methyl-5-(Trifluoromethyl)-1H-Pyrazol-3-Yl]Thiophene-2-Sulfonyl Chloride | HCID 2775671 | — |
| 生成物 | Ethyl {2-[({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate | HCID 10140655 | — |
反応手順
The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-sulfonyl chloride as described in the synthetic METHOD B giving a yellow solid with a purity of 93%. MS (electrospray, [M+H]+) m/z 481.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618961B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-af86f5c33c524254b774fe3b4a53e8eb |
| 出典メモ | uspto-grants-2009_11 |