4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate

HRID 1435651

反応式

HRID 1435651 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][S:14][C:15]1[N:20]=[C:19]([C:21]2[S:25][C:24]([S:26](Cl)(=[O:28])=[O:27])=[CH:23][CH:22]=2)[CH:18]=[CH:17][N:16]=1>>[CH3:13][S:14][C:15]1[N:20]=[C:19]([C:21]2[S:25][C:24]([S:26]([NH:1][C:2]3[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=3)(=[O:28])=[O:27])=[CH:23][CH:22]=2)[CH:18]=[CH:17][N:16]=1

参加物

3

反応物 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27369955-(2-(Methylthio)-4-pyrimidinyl)-2-thiophenesulfonyl chloride

生成物 1

HCID 10115258Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate

実験手順

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-[2-(methylthio)pyrimidin-4-yl]thiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (34.5 mg) with purity >90%. MS (pos) m/z 475.3.

出典と根拠

ORDレコード
ord-750e8d3bccc5492d973356b02e800870
出典データセット
uspto-grants-2009_11
特許番号
US07618961B2

関連ノート

読み込み中…