4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(2,4,6-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435674

反応式

HRID 1435674 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[C:15]=1[S:22]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:24])=[O:23]

参加物

3

反応物 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27769832,4,6-Trifluorobenzenesulfonyl chloride

生成物 1

HCID 10110297Ethyl (2-{[(2,4,6-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

実験手順

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,4,6-trifluorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (1.0 mg) with purity >90%. MS (pos) m/z 381.4.

出典と根拠

ORDレコード
ord-6a3ca502d9984c77b9680e1a8aadb839
出典データセット
uspto-grants-2009_11
特許番号
US07618961B2

関連ノート

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