3-Chloro-2-methylbenzenesulfonyl chloride → Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate

HRID 1435688ノート

反応式

HRID 1435688 の反応式
[NH2:1][C:2]1[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=1.[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20]([NH:1][C:2]2[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

参加物

3

反応物 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 2763571Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate

生成物 1

HCID 86594953Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate

実験手順

The title compound was prepared from methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (23.2 mg) with purity >90%. LCMS (pos) m/z 375.2.

出典と根拠

ORDレコード
ord-259cae2180724468aaea4a556ffa5cae
出典データセット
uspto-grants-2009_11
特許番号
US07618961B2

反応ノート

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