(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amine → 4-(5-Chloro-2-methyl-phenyl)-6-methoxy-[1,3,5]triazin-2-yl-amine

HRID 1435736

反応式

HRID 1435736 の反応式
BrC1C=CC([NH:8][C:9]2[N:14]=[C:13](Cl)[N:12]=[C:11]([C:16]3[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=3[CH3:23])[N:10]=2)=CC=1.[CH3:24][O-:25].[Na+]>CO>[Cl:22][C:20]1[CH:19]=[CH:18][C:17]([CH3:23])=[C:16]([C:11]2[N:12]=[C:13]([O:25][CH3:24])[N:14]=[C:9]([NH2:8])[N:10]=2)[CH:21]=1

参加物

4

反応物 2

HCID 10179730(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amineHCID 10942334Sodium Methoxide

生成物 1

HCID 1317266574-(5-Chloro-2-methyl-phenyl)-6-methoxy-[1,3,5]triazin-2-yl-amine収率 59%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of the title compound of Example 20 (100 mg, 0.25 mmol) in methanol (5 ml) was added a solution of sodium methoxide in methanol (25-30%, 0.5 ml). After stirring for 72 hours, the mixture was concentrated under reduced pressure. The residue was stirred with water (20 ml). The solid was collected by filtration, washed with hexane (5 ml), and dried under reduced pressure to provide the title compound (60 mg, 59% yield). 1H NMR (DMSO-d6) 10.40 (s, 1H), 7.90 (s, 1H), 7.75 (m, 2H), 7.48-7.55 (m, 3H), 7.38 (m, 1H), 3.98 (s, 3H), 2.54 (s, 3H).

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. stirringThe residue was stirred with water (20 ml)
  3. filtrationThe solid was collected by filtration
  4. washwashed with hexane (5 ml)
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a3ce3eb0130b4e7db76b166cc7e684b6
出典データセット
uspto-grants-2009_11
特許番号
US07618968B2

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