1H-Indazol-5-amine → [4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-(1H-indazol-5-YL)-amine

HRID 1435764

反応式

HRID 1435764 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH3:16])[N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][N:22]=[CH:21]2>>[Cl:8][C:6]1[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH3:16])[N:3]=[C:2]([NH:17][C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[NH:23][N:22]=[CH:21]3)[N:7]=1

参加物

3

反応物 2

HCID 880121H-Indazol-5-amineHCID 858270322,4-Dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine

生成物 1

HCID 86588972[4-Chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-(1H-indazol-5-YL)-amine収率 7%

実験手順

The reaction of 2,4-dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine and 5-aminoindazole using the method described in Example 37 provided the title compound (7% yield). 1H NMR (DMSO-d6) 12.95 (s, 1H), 9.52 (br s, 1H), 8.25 (s, 1H), 7.94 (s, 1H), 7.75 (m, 1H), 7.52 (m, 2H), 7.35-7.45 (m, 3H), 7.30 (m, 1H), 7.12)br s, 2H), 2.50 (s, 3H).

出典と根拠

ORDレコード
ord-c1a9327a8567414fba73f7f3c8592498
出典データセット
uspto-grants-2009_11
特許番号
US07618968B2

関連ノート

読み込み中…