Water → cis-3-(1H-indol-3-yl)-indan-1-ol
反応式
C[O-].[Na+].[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C@@H:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C@H:15]([O:22]C(=O)CCC)[CH2:14]2)=[CH:5]1.[NH4+].[Cl-].O>CO>[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C@@H:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C@H:15]([OH:22])[CH2:14]2)=[CH:5]1参加物
6
実験手順
3 mL 30% NaOMe in methanol was added to 13.49 g butyric acid (1R,3S)-3-(1H-indol-3-yl)-indan-1-yl ester in 100 mL methanol. TLC showed full conversion after 1.5 hours. 1.5 g solid NH4Cl and 50 mL water were added. Methanol was removed in vacuo and after aqueous work up, (1R,3S)-3-(1H-indol-3-yl)-indan-1-ol (37.9 mmol ) was obtained.
後処理
- customafter 1.5 hours
- customMethanol was removed in vacuo
出典と根拠
- ORDレコード
- ord-43a20ef6ae0c4929a9655bac2755a109
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618967B2
反応ノート
読み込み中…