[CH3:1][S:2][C:3]1[C:8]2[CH:9]=[C:10]([C:12]([O:14]C)=O)[NH:11][C:7]=2[CH:6]=[CH:5][N:4]=1.CC(C)([O-])C.[K+].[C:22]([O:26][CH3:27])(=[O:25])[CH:23]=[CH2:24]>C1(C)C=CC=CC=1>[CH3:1][S:2][C:3]1[C:8]2[CH:9]=[C:10]3[N:11]([C:7]=2[CH:6]=[CH:5][N:4]=1)[CH2:24][CH:23]([C:22]([O:26][CH3:27])=[O:25])[C:12]3=[O:14]To a suspension of methyl 4-(methylthio)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (0.30 g, 1.35 mmol) in TBF (3 mL)-toluene (12.0 mL) were added a 1.06 M THE solution of potassium tert-butoxide (1.42 mL/1.41 mmol) and methyl acrylate (300 μL). The resulting mixture was heated at 80° C. for 18 h. The mixture was partitioned between EtOAc and NH4Cl, filtered through celite. The organic phase was separated, dried over Na2SO4 and filtered, to provide the title compound.
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