Phosphorus oxychloride → 5-Bromo-1-chloro-6-methoxyisoquinoline

HRID 1436012

反応式

HRID 1436012 の反応式
O=P(Cl)(Cl)Cl.[ClH:6].[Br:7][C:8]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][N+:12]([O-])=[CH:13]2>>[Br:7][C:8]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][N:12]=[C:13]2[Cl:6]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 688780245-bromo-6-methoxyisoquinoline-N-oxide hydrochloride

生成物 1

HCID 579564605-Bromo-1-chloro-6-methoxyisoquinoline収率 110.1%

反応条件

温度
90 °C

実験手順

POCl3 (6.5 ml) was added to the 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g) and the mixture heated at 90° C. for 6 h. Excess POCl3 was removed in vacuo and the remaining solid washed with water, filtered and dried in vacuo to give 5-bromo-1-chloro-6-methoxyisoquinoline (1.26 g).

後処理

  1. customExcess POCl3 was removed in vacuo
  2. washthe remaining solid washed with water
  3. filtrationfiltered
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-f1c98be2325144308728bc9ba854eb7e
出典データセット
uspto-grants-2009_11
特許番号
US07618985B2

関連ノート

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