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3-(Boc-amino)piperidine → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| 反応物 | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | 1,932.7% |
| 生成物 | 3-(Tert-butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242669 | — |
| 生成物 | (r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242690 | — |
反応手順
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18) is prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg (predictive yield)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618984B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-126c299982984ca3a1f4790663298875 |
| 出典メモ | uspto-grants-2009_11 |