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3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine | HCID 2761404 | — |
| 反応物 | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| 反応物 | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| 反応物 | 1-Chloro-4-fluoro-5-isoquinolinesulfonyl chloride | HCID 86613861 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86613860 | — |
| 生成物 | HCID 178484870 | HCID 178484870 | — |
反応手順
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 27b) is prepared by using 1-chloro-4-fluoro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxy-carbonyl)-N-methylamino]pyrrolidine in the method of Example 35, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35, Step B in a similar manner to obtain the title compound as hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618984B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-5898350fbe1642688eb02f66d9a5eb81 |
| 出典メモ | uspto-grants-2009_11 |