Hydrochloride methanol → Hydrochloric Acid

反応式

C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:29].CO>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:29]

参加物

反応物 2

HCID 21893726Hydrochloride methanol

HCID 67243409(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidine

生成物 2

HCID 313Hydrochloric Acid

HCID 67242686(r/s)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

実験手順

Intermediate 28 (30 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at room temperature for 20 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg (predictive yield)).

後処理

customThe solvent is evaporated under reduced pressure

出典と根拠

ORDレコード: ord-64145771ea8e43808e68985d8cdf132d
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07618984B2

反応ノート

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