Hydrochloric Acid → 2-Chloro-N-(pyridin-4-yl)quinazolin-4-amine

HRID 1436237ノート

反応式

HRID 1436237 の反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1.Cl>C(O)(C)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 17274-AminopyridineHCID 2528862,4-Dichloroquinazoline

生成物 1

HCID 226932532-Chloro-N-(pyridin-4-yl)quinazolin-4-amine収率 61.9%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a stirred suspension of 2,4-dichloroquinazoline (42 mg, 0.21 mmol) and 4-aminopyridine (21 mg, 0.22 mmol) in 3 mL of anhydrous isopropanol was added a drop of concentrated HCl and the mixture was stirred overnight. Solid precipitates were observed and the mixture was filtered. The solid was washed with cold isopropanol and dried to give the title compound as white solid (38 mg, 0.13 mmol, 61%). 1H NMR (DMSO-d6): 8.60 (d, J=7.5 Hz, 2H), 8.18-8.20 (m, 2H), 8.07-8.10 (m, 1H), 7.90-7.96 (m, 1H), 7.18 (d, J=7.8 Hz, 2H).

後処理

  1. customSolid precipitates
  2. filtrationthe mixture was filtered
  3. washThe solid was washed with cold isopropanol
  4. customdried

出典と根拠

ORDレコード
ord-7ea2936be0e74cc08e7cfb99e4fc2ba9
出典データセット
uspto-grants-2009_11
特許番号
US07618975B2

反応ノート

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