2,3-Dimethoxyaniline → 2-Chloro-N-(2,3-dimethoxyphenyl)quinazolin-4-amine

反応式

[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O:14][C:15]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][C:16]=1[NH2:17]>>[Cl:1][C:2]1[N:11]=[C:10]([NH:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:21]([O:22][CH3:23])[C:15]=2[O:14][CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

反応物 2

HCID 2396032,3-Dimethoxyaniline

HCID 2528862,4-Dichloroquinazoline

生成物 1

HCID 579388092-Chloro-N-(2,3-dimethoxyphenyl)quinazolin-4-amine

実験手順

The title compound was prepared from 2,4-dichloroquinazoline and 2,3-dimethoxyaniline by a procedure similar to example 28 (84% yield). 1H NMR (CDCl3): 8.57 (s, broad, 1H), 8.38 (d, J=8.4 Hz, 1H), 7.77-7.86 (m, 3H), 7.55-7.61 (m, 1H), 7.15 (t, J=8.7 Hz, 1H), 6.73-6.75 (m, 1H), 4.00 (s, 3H), 3.91 (s, 3H).

出典と根拠

ORDレコード: ord-a7c54c2a99384c689b207d5756523beb
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07618975B2

反応ノート

読み込み中…