4-(Bromoacetyl)benzonitrile → 4-{2-[(2-Hydroxy-1,1-dimethylethyl)amino]-1,3-thiazol-4-yl}benzonitrile

HRID 1436422ノート

反応式

HRID 1436422 の反応式
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=O.[OH:13][CH2:14][C:15]([NH:18][C:19]([NH2:21])=[S:20])([CH3:17])[CH3:16]>C(O)C>[OH:13][CH2:14][C:15]([NH:18][C:19]1[S:20][CH:2]=[C:3]([C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=2)[N:21]=1)([CH3:17])[CH3:16]

参加物

4

反応物 2

HCID 986544-(Bromoacetyl)benzonitrileHCID 22768414N-(1-Hydroxy-2-methylpropan-2-yl)thiourea

生成物 1

HCID 866185984-{2-[(2-Hydroxy-1,1-dimethylethyl)amino]-1,3-thiazol-4-yl}benzonitrile収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

This compound was prepared in the same manner as described in step 3 of Example 81. 4-(2-bromoacetyl)benzonitrile (1.7 g, 7.4 mmol) and N-(2-hydroxy-1,1-dimethylethyl)thiourea (1.1 g, 7.4 mmol), prepared in step 2 of Example 52, were heated to reflux in 45 mL of ethanol for 30 min. The reaction mixture was cooled to room temperature and the crude product was collected by suction filtration to give 4-{2-[(2-hydroxy-1,1-dimethylethyl)amino]-1,3-thiazol-4-yl}benzonitrile (2.0 g, 100%), MS (ES) m/z 274 [M+H]+. No further purification was performed on this compound.

後処理

  1. customThis compound was prepared in the same manner
  2. temperaturewere heated
  3. filtrationthe crude product was collected by suction filtration

出典と根拠

ORDレコード
ord-20d1ae95970b4f6a9940e23334d58b1c
出典データセット
uspto-grants-2009_11
特許番号
US07618990B2

反応ノート

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