Isothiocyanatopotassium → 1-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([F:12])[CH:6]=1)=[O:4].[N-:13]=[C:14]=[S:15].[K+]>C(O)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:15][C:14]#[N:13])=[CH:6][C:7]=1[F:12]参加物
4
実験手順
In the same manner as described in step 4 of Example 78, using 2-bromo-1-(4-chloro-3-fluoro-phenyl)-ethanone (2.7 g, 10.7 mmol), prepared in the previous step, and potassium isothiocyanate (1.25 g, 12.8 mmol) in ethanol (150 mL) the crude product was collected by suction filtration to give 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.47 g, 100%), which was used in the next step without further purification. MS (ES) m/z 230[M+H+].
後処理
- filtrationwas collected by suction filtration
出典と根拠
- ORDレコード
- ord-7e06f8fe6fc743dfb43f3131c67df4b5
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618990B2
反応ノート
読み込み中…