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Sodium Hydroxide → 3-Bromo-5-(methoxycarbonyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Bromoisophthalic acid | HCID 90073 | — |
| 反応物 | 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester | HCID 103954 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Bromo-5-(methoxycarbonyl)benzoic acid | HCID 22593641 | — |
反応手順
Add a solution of NaOH pellets (3.66 g, 91.5 mmol) in methanol (200 mL) to dimethyl-5-bromoisophthalate (25 g) and stir the resulting solution overnight at room temperature. Add water (300 mL) and extract with dichloromethane (3×200 mL). Acidify the aqueous with 5 N HCl (20 mL), filter the precipitate and dry to give a mixture of the title compound and 5-bromo-isophthalic acid in about a 6:4 ratio by LCMS (18.2 g crude).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618978B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-40960b307c61456d9b46c0fd87310bf3 |
| 出典メモ | uspto-grants-2009_11 |