Trimethyl orthoformate → HCID 23137711、化合物

HRID 1436893ノート

反応式

HRID 1436893 の反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15]C(=O)[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[CH:28]([O:31][CH3:32])[O:29][CH3:30]>CO>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:28]([O:29][CH3:30])([O:31][CH3:32])[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 9005Trimethyl orthoformateHCID 21927685HCID 21927685、化合物

生成物 1

HCID 23137711HCID 23137711、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 132 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine were added 650 ml of methanol, 84 ml of trimethoxymethane and 2 g of strongly acidic resin IR-120 (manufactured by Japan Organo Co., Ltd.), and the mixture was stirred at room temperature for 3 days. From the reaction mixture was removed insoluble matters by filtration, and the solvent was removed by distillation under reduced pressure, to give 146 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine as shown in Table 125 below.

後処理

  1. customFrom the reaction mixture was removed insoluble matters
  2. filtrationby filtration
  3. customthe solvent was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-eaad82ecf3334b43a61336aa5a4336d1
出典データセット
uspto-grants-2009_11
特許番号
US07619092B2

反応ノート

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