Sodium methanethiolate → HCID 69018301、化合物
反応式
Cl[CH2:2][C@@H:3]([NH:13][C:14](=[O:16])[CH3:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[CH3:17][S-:18].[Na+]>CN1CCCC1=O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C@H:3]([NH:13][C:14](=[O:16])[CH3:15])[CH2:2][S:18][CH3:17])=[CH:6][CH:7]=1参加物
4
実験手順
The N-[(1S)-2-chloro-1-(4-methoxybenzyl)ethyl]acetamide in solution in N-methylpyrrolidone prepared in the preceding stage is added to a suspension of sodium thiomethoxide (1.8 g) in 3.8 ml of N-methylpyrrolidone at 20° C. The reaction medium is brought to 40° C. for 2 hours. The product formed is precipitated by addition of 5.7 ml of water. After filtration and drying, 3.7 g of N-[(1S)-1-(4-methoxybenzyl)-2-(methylthio)ethyl]acetamide are isolated.
後処理
- customThe product formed
- customis precipitated by addition of 5.7 ml of water
- filtrationAfter filtration
- customdrying
出典と根拠
- ORDレコード
- ord-f967e49015e44454a678c5b90ff656ec
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07619116B2
反応ノート
読み込み中…