2-Bromoethyl methyl ether → 1-(2-Methoxyethyl)-3-(4-piperidinyl)-1H-pyrrolo[2,3-b]pyridine

反応式

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[N:18][CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Br[CH2:24][CH2:25][O:26][CH3:27]>>[CH3:27][O:26][CH2:25][CH2:24][N:16]1[C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:22]2[C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:15]1

参加物

反応物 2

HCID 809722-Bromoethyl methyl ether

HCID 49758876tert-butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate

生成物 1

HCID 179729681-(2-Methoxyethyl)-3-(4-piperidinyl)-1H-pyrrolo[2,3-b]pyridine

実験手順

This compound was prepared following the procedure described in example 7, parts E and F, starting with 0.2 g (0.66 mmol) of 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester and 0.081 ml (0.864 mmol) of 1-bromo-2-methoxyethane. After standard work-up, 0.15 g (100% of yield) of the expected product were isolated.

後処理

customThis compound was prepared

出典と根拠

ORDレコード: ord-fac1dca7de824cb9baf9a8673892da43
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07622480B2

反応ノート

読み込み中…

参加物