Triethylamine → (S)-Methyl morpholine-3-carboxylate

HRID 1437276ノート

反応式

HRID 1437276 の反応式
C(N(CC)CC)C.[CH3:8][O:9][C:10](=[O:18])[C@@H:11]([NH2:17])[CH2:12][O:13][CH2:14][CH2:15]Cl>CO>[CH3:8][O:9][C:10]([C@@H:11]1[CH2:12][O:13][CH2:14][CH2:15][NH:17]1)=[O:18]

参加物

4

反応物 2

HCID 8471TriethylamineHCID 86605437HCID 86605437、化合物

生成物 1

HCID 6558896(S)-Methyl morpholine-3-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Triethylamine (1.2 mL) was added to the above-obtained (2S)-2-amino-3-(2-chloroethoxy)propanoic acid methyl ester (726 mg) in methanol (10 mL), and the resultant mixture was refluxed under heat for 3 hours, and then cooled in air. The reaction solvent was removed under reduced pressure. Ethyl acetate was added to the residue, and insoluble matter was removed by filtration. The solvent of the filtrate was removed under reduced pressure, to thereby give the title compound as an oily product (467 mg, 80%).

後処理

  1. temperatureunder heat for 3 hours
  2. temperaturecooled in air
  3. customThe reaction solvent was removed under reduced pressure
  4. additionEthyl acetate was added to the residue, and insoluble matter
  5. customwas removed by filtration
  6. customThe solvent of the filtrate was removed under reduced pressure

出典と根拠

ORDレコード
ord-1e69003d772f40dcaa0000907fd03886
出典データセット
uspto-grants-2009_11
特許番号
US07622471B2

反応ノート

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