(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol → 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde

HRID 1437329

反応式

HRID 1437329 の反応式
[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH2:11][OH:12])[CH:9]=[CH:10][C:2]1=2>ClCCl.[O-2].[O-2].[Mn+4]>[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH:11]=[O:12])[CH:9]=[CH:10][C:2]1=2

参加物

4

反応物 1

HCID 18454501(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol

生成物 1

HCID 184545003,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde収率 50.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

The alcohol (a) (0.482 g) in dry dichloromethane (50 ml) was stirred with manganese dioxide (1.2 g) for 18 hours and the mixture was filtered. The filtrate was evaporated and chomatographed on silica gel, eluting with methanol-dichloromethane (1:50) to afford a yellow solid (0.24 g).

後処理

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated
  3. washeluting with methanol-dichloromethane (1:50)

出典と根拠

ORDレコード
ord-e0ff8619783e438fb1a37a91f64277fb
出典データセット
uspto-grants-2009_11
特許番号
US07622481B2

関連ノート

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