6-Amino-5-ethoxycarbonylmethylthio-3-fluoropyridine-2-carboxylic acid methyl ester → Methyl 7-fluoro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

HRID 1437353ノート

反応式

HRID 1437353 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:10]([F:11])=[CH:9][C:8]([S:12][CH2:13][C:14](OCC)=[O:15])=[C:7]([NH2:19])[N:6]=1)=[O:4]>C(O)(=O)C>[F:11][C:10]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[N:6][C:7]2[NH:19][C:14](=[O:15])[CH2:13][S:12][C:8]=2[CH:9]=1

参加物

3

反応物 1

HCID 218736466-Amino-5-ethoxycarbonylmethylthio-3-fluoropyridine-2-carboxylic acid methyl ester

生成物 1

HCID 21873675Methyl 7-fluoro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate収率 105%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of the fluoropyridine (b) (1.7 g) in acetic acid (100 ml) was heated at 110° C. overnight, evaporated and dried under vacuum to give the product as a white solid (1.5 g).

後処理

  1. customevaporated
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-61a85413ed4f475b9f1b6ade32b7f3b1
出典データセット
uspto-grants-2009_11
特許番号
US07622481B2

反応ノート

読み込み中…