Cesium fluoride → 3-Methoxyquinoxalin-5-ol
反応式
[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[C:5](=[C:6]([O:13][Si](C(C)C)(C(C)C)C(C)C)[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[F-].[Cs+]>O1CCCC1.CO>[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:13])[C:5]=2[N:4]=1参加物
4
実験手順
A solution of (d) (6.95 g, 21 mmol) in tetrahydrofuran/methanol (280 ml/140 ml) was treated with caesium fluoride (4.73 g, 31.4 mmol) and stirred for 18 hours. The mixture was evaporated and the residue partitioned between diethyl ether and dilute aqueous hydrochloric acid. The aqueous phase was further extracted with diethyl ether and the combined extracts dried and evaporated to give an oil (4.2 g).
後処理
- customThe mixture was evaporated
- customthe residue partitioned between diethyl ether and dilute aqueous hydrochloric acid
- extractionThe aqueous phase was further extracted with diethyl ether
- customthe combined extracts dried
- customevaporated
出典と根拠
- ORDレコード
- ord-e352872d5e004c98b4fdadc92c7b0840
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622481B2
反応ノート
読み込み中…