Lithium hydroxide, monohydrate → HCID 68700284、化合物
反応式
C[O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][C@@H:8]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C@H:7]([O:19][CH3:20])[CH2:6]1)=[O:4].O.[OH-].[Li+]>CO.O>[C:15]([O:14][C:12]([NH:11][C@@H:8]1[CH2:9][CH2:10][C@@H:5]([C:3]([OH:4])=[O:2])[CH2:6][C@H:7]1[O:19][CH3:20])=[O:13])([CH3:18])([CH3:17])[CH3:16]参加物
4
実験手順
The ester (e) (5.47 g, 19 mmol) and lithium hydroxide monohydrate (0.96 g, 23 mmol) in methanol/water (50 ml/50 ml) were stirred at room temperature for 18 hours then evaporated to dryness. The residue was partitioned between ethyl acetate and water (30 ml) containing sodium dihydrogen phosphate (7 g). The aqueous phase was further extracted with ethyl acetate and the combined extracts washed with brine, dried and evaporated to give a solid (5.0 g, 96%).