1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 4-Hydroxyquinoline-6-carbonitrile

HRID 1437387ノート

反応式

HRID 1437387 の反応式
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)C(=O)O1.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>CCOCC>[O:8]=[C:6]1[C:12]2[C:11](=[CH:18][CH:17]=[C:14]([C:15]#[N:16])[CH:13]=2)[NH:10][CH:9]=[CH:5]1

参加物

4

反応物 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 116947054-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

生成物 1

HCID 116583514-Hydroxyquinoline-6-carbonitrile収率 94.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Benzonitrile (a) (27.5 g) was added portionwise over 5 minutes to refluxing Dowtherm A (200 ml). After refluxing an additional 5 minutes, the mixture was allowed to cool to room temperature and diluted with ether (200 ml) with stirring. The product was filtered off, washed thoroughly with ether and air dried to provide a gold solid (16.2 g, 94%).

後処理

  1. temperatureAfter refluxing an additional 5 minutes
  2. filtrationThe product was filtered off
  3. washwashed thoroughly with ether and air
  4. customdried

出典と根拠

ORDレコード
ord-3be0c4741a29485f881d876f25db75a7
出典データセット
uspto-grants-2009_11
特許番号
US07622481B2

反応ノート

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