Benzyl Bromide → 8-Benzyloxy-3-methyl-1H-quinolin-2-one

HRID 1437389ノート

反応式

HRID 1437389 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[OH:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[NH:24][C:23](=[O:26])[C:22]([CH3:27])=[CH:21]2>CC(C)=O>[CH2:1]([O:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[NH:24][C:23](=[O:26])[C:22]([CH3:27])=[CH:21]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 4409863-Methyl-quinolin-2,8-diol

生成物 1

HCID 224992238-Benzyloxy-3-methyl-1H-quinolin-2-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.

後処理

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. filtrationfiltered
  3. customevaporated
  4. custompurified by flash column chromatography on silica gel
  5. washeluting with 2% methanol in dichloromethane

出典と根拠

ORDレコード
ord-224b39315ef9427bafec00e63d3ef219
出典データセット
uspto-grants-2009_11
特許番号
US07622483B2

反応ノート

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