Aniline → 2,3,4,9-tetrahydro-1H-carbazol-1-one

HRID 1437505

反応式

HRID 1437505 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OC=[C:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=[O:16]>>[C:11]1(=[O:16])[C:10]2[NH:1][C:2]3[C:7](=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:15]=2[CH2:14][CH2:13][CH2:12]1

参加物

3

反応物 2

HCID 6115AnilineHCID 101871Cyclohexanone, 2-(hydroxymethylene)-

生成物 1

HCID 2858652,3,4,9-tetrahydro-1H-carbazol-1-one

実験手順

2,3,4,9-Tetrahydro-1H-carbazol-1-one was prepared from aniline (2.9 g, 31 mmol) and 2-(hydroxymethylene)cyclohexanone (3.5 g, 28 mmol) in a similar manner as described above to give 2.5 g (49%). of a brown solid. 1H-NMR (DMSO-d6): δ 11.6 (s, 1H), 7.66 (d, 1H), 7.38 (d, 1H), 7.30 (t, 1H), 7.07 (t, 1H), 2.90 (t, 2H), 2.56 (t, 2H), 2.15 (m, 2H); MS m/z 186 (M+1).

後処理

  1. customto give 2.5 g (49%)

出典と根拠

ORDレコード
ord-60896bd3a9e9436bb8962aa04e493499
出典データセット
uspto-grants-2009_11
特許番号
US07622494B2

関連ノート

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