2,5-Dimethoxybenzyl alcohol → cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidine

HRID 1437642ノート

反応式

HRID 1437642 の反応式
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:30][O:31][C:32]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][C:33]=1[CH2:34]O>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([CH2:34][C:33]2[CH:36]=[C:37]([O:40][CH3:41])[CH:38]=[CH:39][C:32]=2[O:31][CH3:30])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

3

反応物 2

HCID 1184952,5-Dimethoxybenzyl alcoholHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

生成物 1

HCID 86606820cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidine収率 23.8%

実験手順

The compound (0.20 g) obtained in Example 1 and 2,5-dimethoxybenzyl alcohol (0.12 g) were reacted and treated in the same manner as in the method described in Example 16 to obtain the title compound as colorless oil (0.060 g, 23%).

後処理

  1. additiontreated in the same manner as in the method

出典と根拠

ORDレコード
ord-e54581387f2a4aa19380b4d168e09077
出典データセット
uspto-grants-2009_11
特許番号
US07622487B2

反応ノート

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