Hydrochloric Acid → 5-(3-Piperidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic Acid Hydrochloride
反応式
C([O:3][C:4]([C:6]1[NH:24][C:9]2=[N:10][CH:11]=[C:12]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:13]=[C:8]2[CH:7]=1)=[O:5])C.[ClH:25]>O1CCOCC1>[ClH:25].[N:18]1([CH2:17][CH2:16][CH2:15][O:14][C:12]2[CH:13]=[C:8]3[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:24][C:9]3=[N:10][CH:11]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1参加物
4
実験手順
To the solution of 0.18 g (0.54 mmol) 5-(3-piperidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester in 1.2 ml dioxan, 0.54 ml (0.64 g) concentrated hydrochloric acid were added. The reaction mixture was heated under reflux for 18 h, evaporated and dried under high vacuum over phosphorus pentoxide to give 0.18 g (100%) of the compound as a light brown solid.