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Potassium Carbonate → (4,4-Difluoro-piperidin-1-yl)-[5-[3-((2r,5r)-2,5-dimethyl-pyrrolidin-1-yl)-propoxy]-1h-pyrrolo[2,3-b]pyridin-2-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,5-Dimethylpyrrolidine, (2R,5R)- | HCID 641767 | — |
| 反応物 | [5-(3-Chloro-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68424352 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (4,4-Difluoro-piperidin-1-yl)-[5-[3-((2r,5r)-2,5-dimethyl-pyrrolidin-1-yl)-propoxy]-1h-pyrrolo[2,3-b]pyridin-2-yl]-methanone | HCID 16727338 | 6% |
反応手順
The title compound was synthesized in analogy to example 1, intermediate a), from [5-(3-chloro-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone, (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available) and potassium carbonate in acetonitrile to give 23 mg (6%) of the desired product as a light yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07622466B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-eaf599336a614d43b7b5c750f299e0fd |
| 出典メモ | uspto-grants-2009_11 |