Potassium Cyanide → 2,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

HRID 1438149ノート

反応式

HRID 1438149 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]=[O:5].[C-:13]#[N:14].[K+].OS([O-])=O.[Na+]>C(OCC)(=O)C.O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]([OH:5])[C:13]#[N:14]

参加物

6

反応物 3

HCID 9032Potassium CyanideHCID 23665763Sodium BisulfiteHCID 578038672,4-Difluoro-5-methoxybenzaldehyde

生成物 1

HCID 579429112,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 98A (506 mg, 2.94 mmol) in ethyl acetate (10 mL) was added a solution of KCN (574 mg, 8.82 mmol) and NaHSO3 (917 mg, 8.82 mmol) dissolved in H2O (10 mL). The reaction was stirred at rt for 48 h. It was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated to give 98B as an oil. It was used for next step without purification.

後処理

  1. extractionIt was extracted with ethyl acetate (2×50 mL)
  2. customThe combined organic extracts were dried
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-d12308c8358c46069e65ba7d4d129058
出典データセット
uspto-grants-2009_11
特許番号
US07622585B2

反応ノート

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