化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Cyanide → 2-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 3-(Difluoromethoxy)benzaldehyde | HCID 2736985 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile | HCID 54493847 | 92.9% |
反応手順
To 3-difluoromethoxybenzaldehyde (1.77 g, 10 mmol) in ethyl acetate (25 mL) was added a solution of KCN (2.0 g) and NaHSO3 (3.2 g) dissolved in H2O (25 mL). It was left stirring overnight before it was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated. The crude product was purified by silica gel chromatography to give 131A (1.85 g, 92% yield) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07622585B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-6d746ab88683482984bcbc8e121a4e74 |
| 出典メモ | uspto-grants-2009_11 |